Petersen and Fred Possmayer Ruud
نویسندگان
چکیده
year physiology, especially those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a publishes original papers that deal with diverse area of research in applied
منابع مشابه
Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant.
Mechanical ventilation is an essential but potentially harmful therapeutic intervention for patients with acute lung injury. The objective of this study was to investigate the effects of mechanical ventilation on large-aggregate surfactant (LA) structure and function. Isolated rat lungs were randomized to either a nonventilated control group, a relatively noninjuriously ventilated group [1 h, 1...
متن کاملRecent advances in alveolar biology: some new looks at the alveolar interface.
This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and e...
متن کاملDisparate Effects of Two Phosphatidylcholine Binding Proteins, C-reactive Protein (crp) and Surfactant Protein a (sp-a) on Pulmonary Surfactant Structure and Function
KAUSHIK NAG 1*, KARINA RODRIGUEZ-CAPOTE *, AMIYA KUMAR PANDA, LAURA FREDERICK , STEPHEN A. HEARN , NILS O. PETERSEN , SAMUEL SCHÜRCH and FRED POSSMAYER 1. 1 Departments of Obstetrics and Gynaecology, 2 Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, 3 Department of Chemistry, University of Western Ontario, London, Ontario, Canada N6A 5A5, Departamento ...
متن کاملCurrent perspectives in pulmonary surfactant--inhibition, enhancement and evaluation.
Pulmonary surfactant (PS) is a complicated mixture of approximately 90% lipids and 10% proteins. It plays an important role in maintaining normal respiratory mechanics by reducing alveolar surface tension to near-zero values. Supplementing exogenous surfactant to newborns suffering from respiratory distress syndrome (RDS), a leading cause of perinatal mortality, has completely altered neonatal ...
متن کاملAtomic force microscopy studies of functional and dysfunctional pulmonary surfactant films, II: albumin-inhibited pulmonary surfactant films and the effect of SP-A.
Pulmonary surfactant (PS) dysfunction because of the leakage of serum proteins into the alveolar space could be an operative pathogenesis in acute respiratory distress syndrome. Albumin-inhibited PS is a commonly used in vitro model for studying surfactant abnormality in acute respiratory distress syndrome. However, the mechanism by which PS is inhibited by albumin remains controversial. This s...
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